Principal Investigators: Nicholas Oberlies
Application Number: 15/557,639
UNCG Innovation: 16-0004
Category: Chemistry & Biochemistry
Description:
Pharmaceutical compositions that include a polyhydroxyanthraquinone. In some embodiments, the composition includes an amount of the 10 polyhydroxyanthraquinone effective to inhibit quorum sensing in a microbe. In other mbodiments, the composition includes an amount of the polyhydroxyanthraquinone effective to antagonize AgrA function in a microbe. In other embodiments, the composition includes an amount of the polyhydroxyanthraquinone effective to attenuate a skin and soft tissue infection (SSTI) of a subject by a microbe. In still other embodiments, the composition includes an mount of the polyhydroxyanthraquinone effective to reduce an inflammatory response in a subject in response to infection by a microbe. In some of these embodiments, the inflammatory response can include producing IL-1β, producing TNFα, producing IL-6.
Immediate & Future Applications:
The idea of treating ‘infection’ with antivirulence compounds could have application in any scenario where there is a wound. This could be wounds from the environment (scrapes), combat (knives, gunshot, etc.), or comorbidity (diabetes). In any scenario where there is an infection, a compound that will help the ‘host’ clear the infection could have value.
Inventor Info: Nicholas Oberlies
- https://chem.uncg.edu/oberlies/
- https://scholar.google.com/citations?user=hmHmqu8AAAAJ&hl=en
- https://chem.uncg.edu/person/nicholas-oberlies/
- https://www.researchgate.net/profile/Nicholas_Oberlies
- https://www.linkedin.com/in/nicholas-oberlies-518b9493
- https://u.osu.edu/naturalproducts/dr-nicholas-oberlies/
- https://www.springer.com/cda/content/document/cda_downloaddocument/Oberlies+.pdf?SGWID=0-0-45-822901-p173621671
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