Compositions and Methods that Inhibit Quorum Sensing

Principal Investigators: Nicholas Oberlies

Application Number: 15/557,639

UNCG Innovation: 16-0004

Category: Chemistry & Biochemistry

Description:
Pharmaceutical compositions that include a polyhydroxyanthraquinone. In some embodiments, the composition includes an amount of the 10 polyhydroxyanthraquinone effective to inhibit quorum sensing in a microbe. In other mbodiments, the composition includes an amount of the polyhydroxyanthraquinone effective to antagonize AgrA function in a microbe. In other embodiments, the composition includes an amount of the polyhydroxyanthraquinone effective to attenuate a skin and soft tissue infection (SSTI) of a subject by a microbe. In still other embodiments, the composition includes an mount of the polyhydroxyanthraquinone effective to reduce an inflammatory response in a subject in response to infection by a microbe. In some of these embodiments, the inflammatory response can include producing IL-1β, producing TNFα, producing IL-6.

Immediate & Future Applications:
The idea of treating ‘infection’ with antivirulence compounds could have application in any scenario where there is a wound. This could be wounds from the environment (scrapes), combat (knives, gunshot, etc.), or comorbidity (diabetes). In any scenario where there is an infection, a compound that will help the ‘host’ clear the infection could have value.

Inventor Info: Nicholas Oberlies

Media: